Epidermalgrowthfactor(EGF)isaproteinthatplaysanimportantroleintheregulationofvariouscellprocesses,includingcellproliferation,migration,survival,anddifferentiation.EGFisamemberoftheEGFfamilythatbindstotheEGFRfamilyofreceptors(alsoknownasErbBreceptors).TheErbBreceptorsconsistoffourtransmembranereceptorsbelongingtothereceptortyrosinekinase(RTK)superfamilyandincludesEGFR(ErbB1/HER-1),ErbB2(neu/HER-2),ErbB3(HER-3),andErbB4(HER-4).FunctionalselectivityofEGFfamilymembersisduetodistinctionsintheconformationoftheligandedreceptorandsubsequentdifferencesinthesitesofreceptortyrosinephosphorylationandreceptorcouplingtosignalingeffectors.RecombinantHumanEGFACFisasingle,non-glycosylatedproteincontaining53aminoacids,withamolecularweightof6.2kDa(1-3).

• AccessionNumber:P01133
• Synonyms:Urogastrone,URG
• Purity:≥95%determinedbyHPLC,reducingandnon-reducingSDS-PAGEanalysis,UVspectroscopyat280nm.
• Bioactivity:TheED₅₀istypicallylessthan15pg/mL.ED₅₀isdeterminedbydose-dependentproliferationofBALB/c3T3cells.
• Animalcomponent-freeandcarrier-free
• Custompackagingavailable

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