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主营:细胞培养基
℡ 4000-520-616
℡ 4000-520-616
Irvine Scientific/Recombinant Human IL-2 ACF/10 µg/95118 - 10 µg
产品编号:95118-10µg
市  场 价:¥1860.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$93.00
品      牌: Irvine
公      司:irvinesci.lnc
公司分类:
Irvine Scientific/Recombinant Human IL-2 ACF/10 µg/95118 - 10 µg
商品介绍

IL-2isaTcellstimulatorycytokinebestknownforinducingactivatedTcellproliferationinvitro.IL-2alsostimulatesproliferationanddifferentiationofBcells,naturalkillercells,monocytesandmacrophages.IL-2iscriticalforthedevelopment,survival,andfunctionofCD4+CD25+regulatoryTcells,whichpromotesTcelltolerancebysuppressingTcellresponsestoself-antigensinvivo,thusinhibitingimmuneresponsesandpreventingautoimmunediseases.IL-2playsanessentialroleinsensitizingTcellstoactivation-inducedcelldeath,aprocessmediatedprimarilybyFasandTNFsignalstolimitthemagnitudeofTcellexpansionthroughprogrammeddeathofactivatedTcells.IL-2bindstoandsignalsthroughmembranereceptorIL-2R,whichisexpressedalmostexclusivelybyactivatedT-cells.IL-2RisatrimericreceptorcomplexconsistingofthreedistinctsubunitsdesignatedasIL-2Rα(CD25),IL-2Rβ(CD122),andcommonγ-chain(γc,CD132).IL-2RαbindsexclusivelytoIL-2withlowaffinityandincreasesbindingaffinityofthewholereceptorcomplex,includingIL-2Rβandγcsubunits.IL-2RβisalsousedbyIL-15.Thecommonγcisusedbyothercytokines,includingIL-4,IL-7,IL-9,IL-15,andIL-21.BindingofIL-2initiatessignalingcascadesinvolvingJak1,Jak3,Stat5andthePI3K/Aktpathways(2-5).RecombinantHumanIL-2ACFhasaserinesubstituteforcysteineatposition126.RecombinantHumanIL-2ACFisanon-glycosylatedprotein,containing134aminoacids,withamolecularweightof15.5kDa.

  • AccessionNumber:P60568
  • Synonyms:Tcellgrowthfactor,TCGF,Aldesleukin
  • Purity:≥90%determinedbyreducingandnon-reducingSDS-PAGEanalysis
  • Bioactivity:TheED50istypicallylessthan1ng/mL.ED50isdeterminedbythedose-dependentproliferationofCD3+Tcells.
  • Animalcomponent-freeandcarrier-free
  • Custompackagingavailable

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品牌介绍

FUJIFILM Irvine Scientific是面向研究人员和临床医生的细胞培养基,试剂和医疗设备创新与制造的全球领导者。该公司为从事细胞治疗和再生医学,辅助生殖技术和细胞遗传学以及工业细胞培养以大规模生产生物治疗剂和疫苗的科学家提供无与伦比的服务和质量。FUJIFILM Irvine Scientific遵守ISO和FDA法规,并在美国加利福尼亚州和日本东京设有cGMP双制造工厂。公司的咨询理念与细胞培养和法规遵从方面的专业知识相结合,为客户提供了独特的功能和支持。

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