GranulocyteMacrophageColonyStimulatingFactor(GM-CSF)isapleiotropiccytokineandamemberofafamilyofendogenouscytokinesofthehematopoieticsystem.GM-CSFisproducedasaresponsetoimmuneorinflammatorystimulibymonocytes,Tcells,macrophagesaswellasfibroblasts.GM-CSFisabletostimulatetheproductionofneutrophilicgranulocytes,macrophages,andmixedgranulocyte-macrophagecoloniesfrombonemarrowcells.GM-CSFcanalsostimulatesomefunctionalactivitiesinmaturegranulocytesandmacrophages.HumanandmouseGM-CSFshownocrossreactivity.RecombinantGM-CSFisanon-glycosylatedproteincontaining127aminoacids,withamolecularweightof14.5kDa.

•AccessionNumber:P04141•Synonyms:CSF-2,Pluripoietin-α,MGI1GM•Purity:≥95%purity.DeterminedbyHPLC,reducingandnon-reducingSDS-PAGE,andUVspectroscopy•Bioactivity:ED50typicallylessthan0.5ng/mL.ED50determinedbydosedependentproliferationofhumanTF1cells.•Animalcomponent-freeandcarrier-free•Custompackagingavailable

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